ORIGINAL RESEARCH article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1592517
Clinical characteristics of diffuse large B-cell lymphoma complicated with multiple primary malignant neoplasms
Provisionally accepted
- The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
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Objective: To investigate the clinical features and prognosis of diffuse large B-cell lymphoma (DLBCL) combined with multiple primary malignant neoplasms (MPMNs).Methods: The clinical data and prognosis of 31 patients with DLBCL combined with MPMNs diagnosed by pathology between January 2012 and April 2024 in the Department of Hematology, Affiliated Hospital of Xuzhou Medical University were retrospectively analyzed. Results: Between January 2012 and April 2024, a total of 937 patients were diagnosed with DLBCL, among whom 31 patients had MPMN, with an incidence rate of 3.3%. The cases were divided into two groups according to the different occurrence intervals of the two tumor types. There were 10 patients in the synchronous MPMN group and 21 in the metachronous MPMN group. Statistically significant differences in gender (P=0.046), lactate dehydrogenase levels (P=0.040), and B symptoms (P=0.022) were noted between the two groups. The median age at first (Age 1) and second (Age 2) malignancy diagnoses was 62 (32–87) and 65 (38–87) years, respectively. The median interval between the two tumors was 15 (0–300) months. Kaplan-Meier survival analysis revealed that Age 1≥60 years, synchronous tumors, International Prognostic Index score of medium, high, and high-risk groups (3–5 points), interval time of two malignancies of <50 months, B symptoms, elevated LDH level, Eastern Collaborative Oncology Group score of ≥2 points, and radiotherapy and chemotherapy for the first tumor were adverse factors affecting overall survival. Conclusions: DLBCL combined with MPMNs is rare in the clinic. Age 1≥60 years and shorter time interval between the two tumors are the main factors affecting poor prognosis. Early diagnosis and treatment of DLBCL with MPMNs should be prioritized clinically to prevent misdiagnosis and enhance patient outcomes.
Keywords: Clinical features, Diffuse large B-cell lymphoma, Multiple primary malignant neoplasms, prognosis, survival analysis
Received: 12 Mar 2025; Accepted: 30 Apr 2025.
Copyright: © 2025 Tian, Gu, Lv, Li, Huang, Li, Zhang, Wang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feng Zhu, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
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