ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1592600
Oncofertility outcomes after fertility-sparing surgery of borderline ovarian tumors with infertility: results of a large retrospective study on controlled ovarian stimulation
Provisionally accepted
- Peking University Third Hospital, Haidian, China
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The optimal management of borderline ovarian tumors (BOTs), particularly the safety and efficacy of in vitro fertilization (IVF) following fertility-sparing surgery (FSS)-remains controversial. This study aimed to evaluate the impact of controlled ovarian stimulation (COS) on oncofertility outcomes in infertile women with BOT after FSS. Methods: This retrospective observational study was conducted at the Reproductive Medical Center, Peking University Third Hospital (Beijing, China), and included 73 infertile BOT patients who underwent IVF between January 2008 and June 2022. Results: Median follow-up was 61.0 months (range:7.0-156.0 months). The BOT recurrence rate was 20.5% (15/73) and the cumulative live birth rate per patient was 57.5% (42/73). There was no significant differences in the number of COS cycles (P = 0.513) or total dose of gonadotropin (Gn) (P = 0.183) between the recurrence and non-recurrence groups. Multivariate analysis identified three independent predictors of oncologic outcomes: Interval from surgery to first IVF (HR:0.07;95%CI:0.01-0.44;
Keywords: Borderline ovarian tumor, Fertility-sparing surgery, Recurrence, Oncofertility, Infertility, Controlled ovarian stimulation
Received: 12 Mar 2025; Accepted: 09 Sep 2025.
Copyright: © 2025 Liang, Zhen, Li, Ma, Yang, Yan, Song and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liang Liang, Peking University Third Hospital, Haidian, China
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