CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1593934
Synchronous Bladder and Retroperitoneal Paragangliomas: An Extremely Rare Entity
Provisionally accepted
- The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital, Quzhou, China
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Paragangliomas (PGLs) are rare neuroendocrine tumors originating from chromaffin cells. The synchronous occurrence of bladder and retroperitoneal PGLs is extremely rare. This case highlights the radiological features of dual-site PGLs and their potential for misdiagnosis as bladder cancer with retroperitoneal lymph node metastasis. A 59-year-old female patient was admitted with a 2-week history of abdominal distention. Imaging showed a highly vascularized 1.3 cm × 1.2 cm nodule on the right wall of the bladder and a retroperitoneal mass measuring 1.8 cm × 3.7 cm adjacent to the left side of the abdominal aorta. Postoperative pathological examination confirmed dual-site PGLs. The multifocal appearance and hypervascular characteristics of these tumors may lead to misdiagnosis as bladder cancer with metastasis.Recognizing the clinical, imaging (such as CT and MRI findings) , and pathological features is crucial for avoiding misdiagnosis and formulating an appropriate treatment plan.
Keywords: Paraganglioma, Bladder tumor, Retroperitoneal tumor, imaging, Surgery
Received: 14 Mar 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Huang, Liu and Zhou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Miaoping Zhou, The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital, Quzhou, China
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