SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1597155
Prognostic effect of pretreatment serum gamma-glutamyl transferase in urological malignancies: a systematic review and meta-analysis
Provisionally accepted
- Shijiazhuang People’s Hospital, Shijiazhuang, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
AbstractBackground: This study aimed to investigate the association between pretreatment serum gamma-glutamyltransferase (GGT) and survival outcomes in patients with urological malignancies, such as urothelial carcinoma (UCa), renal cell carcinoma (RCC), and prostate cancer (PCa).Methods: A comprehensive literature search was conducted in PubMed, Ovid, Web of Science, and the Cochrane Library up to December 2024. Survival outcomes were analyzed through the computation of merged hazard ratios (HRs) and 95% confidence intervals (CIs) using Stata 18.0 software.Results: Ten studies involving 2,817 patients were included in the final analysis. The results indicated that elevated pretreatment serum GGT demonstrated a significant association with poorer overall survival (OS) (HR = 3.32, 95% CI: 2.51-4.39), cancer-specific survival (CSS) (HR = 1.95, 95% CI: 1.26-3.04), and progression-free survival (PFS) (HR = 2.34, 95% CI: 1.72-3.17). Subgroup analyses stratified by cancer type demonstrated that elevated serum GGT served as a significant predictor of OS in UCa (HR 3.11, 95% CI 2.08-4.65), RCC (HR 3.51, 95% CI 2.27-5.43), and PCa (HR 3.61, 95% CI 1.51-8.62). Consistent associations were observed for CSS (Uca: HR 1.88, 95% CI 1.23-2.88) and PFS (Uca: HR 2.58, 95% CI 1.24-3.93; RCC: HR 2.00, 95% CI 1.28-3.13; PCa: HR 2.90, 95% CI 1.34-6.26). No significant publication bias was detected across the included studies.
Keywords: Urologic Neoplasms, gamma-Glutamyltransferase, prognosis, Systematic review, Meta-analysis
Received: 20 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Song, Su, Zhang, Cui, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shiqiang Su, Shijiazhuang People’s Hospital, Shijiazhuang, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.