CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1597367
This article is part of the Research TopicAdvances in Combined Modality Treatments for Prostate CancerView all articles
Prostate Cancer Inducing Secondary Linitis Plastica of the Rectum: A rare Case Report and literature review
Provisionally accepted
- Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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Background: Prostate cancer, the most prevalent male malignancy in Western countries, seldom presents as secondary rectal linitis plastica (RLP). Case presentation: We present an 82-year-old male with a six-month history of altered bowel habits, narrowed stools, and mucous discharge, absent lower urinary tract symptoms. Serum PSA was markedly elevated (392 ng/mL). Imaging demonstrated circumferential rectal thickening, a prostatic mass invading the bladder. MRI revealed a "target sign" with associated diffusion restriction. Colonoscopy identified a circumferential mucosal protrusions resembling grape-like clusters (NICE Type 3). Deep biopsies confirmed prostatic adenocarcinoma (Gleason score 4+3=7). Diagnosis: A multidisciplinary team confirmed prostate cancer with secondary RLP. Treatment: Combination therapy (prophylactic colostomy, leuprorelin, and abiraterone) reduced PSA from 392 to 2.16 ng/mL within eight months. Conclusions: RLP may mimic various gastrointestinal disorders clinically. Clinicians should consider RLP (rectal linitis plastica) in elderly males presenting with gastrointestinal symptoms. Definitive diagnosis requires integration of multi-modality imaging, endoscopy, and histopathological biopsy.
Keywords: prostate cancer, Secondary rectal linitis plastica, Rectal adenocarcinoma, PSA, MRI
Received: 21 Mar 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Li, Zhang, Sun, Zhang, Wang, Gan, Xing, Zhang, Wang and Daixiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Junyi Li, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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