ORIGINAL RESEARCH article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1598069
This article is part of the Research TopicExploring the Breast Tumor Microenvironment: Association to Metastasis, Novel Risk Factors and Novel Treatments and Immunotherapies: Volume II.View all 3 articles
Survival Prognosis Evaluation in Advanced Breast Cancer Patients: A Study on the Application of the Advanced Lung Cancer Inflammation Index
Provisionally accepted
- Guangxi Medical University Cancer Hospital, Nanning, China
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Background: Inflammation and nutritional status play critical roles in tumor initiation and progression. Advanced Lung Cancer Inflammation Index (ALI) has gained widespread attention as a novel biomarker for cancer prognosis evaluation. Methods: This retrospective study analyzed 163 advanced breast cancer patients with distant metastasis (Guangxi Medical University Cancer Hospital, 2016-2023). Patients were stratified into high-ALI (n=64) and low-ALI (n=99) groups via K-means clustering. Kaplan-Meier survival curves with log-rank testing were used to assess survival differences, while Cox proportional hazards models were employed to evaluate the independent prognostic value of ALI. The predictive performance of ALI was assessed using time-dependent ROC curves. Results: High ALI correlated with superior overall survival (log-rank p=0.0024) [HR=2.493 (95%CI 1.350-4.606) p = 0.004]. Multivariate analysis confirmed ALI as an independent prognostic factor (HR=0.39, 95% CI 0.16-0.95, p=0.037). ALI demonstrated stable predictive accuracy with 3-year AUC=0.645 and 5-year AUC=0.650 (C-index=0.65). Subgroup analyses confirmed prognostic consistency across clinical characteristics (p-interaction>0.05). Conclusion: ALI is an independent prognostic factor for advanced breast cancer patients with good predictive ability. It provides an important supplementary prognostic marker for clinical practice and can help optimize personalized treatment strategies.
Keywords: Advanced breast cancer, survival prognosis, advanced lung cancer inflammation index (ALI), Inflammation, Nutritional Status
Received: 22 Mar 2025; Accepted: 20 May 2025.
Copyright: © 2025 Liang, Yang, Yang, Tang, Zhang, Tan and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wenhai Zhang, Guangxi Medical University Cancer Hospital, Nanning, China
Qixing Tan, Guangxi Medical University Cancer Hospital, Nanning, China
Qinghong Qin, Guangxi Medical University Cancer Hospital, Nanning, China
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