CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1598738
This article is part of the Research TopicKidney Cancer Awareness Month 2025: Current Progress and Future Prospects on Kidney Cancer Prevention, Diagnosis and TreatmentView all 8 articles
Papillary renal neoplasm with reverse polarity: a case report and literature review
Provisionally accepted
Diego Gonzalez*
Kris KokoneshiSam Kwon
Ryan Thomas Mathews
Ryan Michael AntarMaher AliAbiye Kassa
Michael Whalen- George Washington University, Washington, D.C., United States
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Introduction: Papillary renal neoplasm with reverse polarity (PRNRP) is a rare subtype of papillary renal cell carcinoma (RCC) with unique morphology, molecular features, and good prognosis. Given its rarity, with less than 100 reported cases, further characterization is needed to enhance diagnostic accuracy and inform management strategies. Case Presentation: We report the case of a 59-year-old African American female with an incidentally discovered 2.1 cm left renal mass on imaging. The patient has a medical history of hypertension, asthma, hyperlipidemia, vertigo, depression/anxiety, and prediabetes. Further evaluation via contrast-enhanced CT confirmed an enhancing renal mass without evidence of metastasis. She underwent a robotic-assisted partial nephrectomy, and postoperative pathology confirmed PRNRP with pT1aNxMxR0 staging and ISUP nuclear grade 1. Immunohistochemical analysis demonstrated positive staining for GATA3, CK7, and EMA, and Vimentin and negative for AMACR and CA IX. Molecular profiling revealed a KRAS mutation, a key feature of PRNRP. Postoperative recovery was uneventful aside from transient vertigo, and no further treatment was required. Conclusion: This case reinforces the distinct morphological and molecular profile of PRNRP, distinguishing it from other papillary RCC subtypes. The indolent behavior, absence of metastatic cases, and characteristic molecular profiling and immunohistochemical markers highlight the importance of accurate classification for optimal patient management. Furthermore, the PD-L1 positivity observed in this case raises potential implications for immune checkpoint therapy, an area warranting further investigation. As PRNRP is recently classified, continued study is essential to refine diagnostic, therapeutic, and surveillance strategies for this rare renal neoplasm.
Keywords: oncology, Renal cell carcinma, renal cancer, Papillary renal neoplasm with reverse polarity (PRNRP), Renal neoplasm
Received: 23 Mar 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Gonzalez, Kokoneshi, Kwon, Mathews, Antar, Ali, Kassa and Whalen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Diego Gonzalez, George Washington University, Washington, D.C., United States
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