REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1598868
Research Progress on FOXM1 in Ovarian Cancer Diagnosis and Therapeutics
Provisionally accepted
- 1Nanchang University, Nanchang, China
- 2Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China
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Ovarian cancer (OC) is the leading cause of cancer-related death among women, presenting a significant threat to their lives and health. Early-stage OC often lacks distinctive clinical symptoms, leading to most patients being diagnosed at advanced stages. Current treatment strategies primarily involve a combination of surgical resection and chemotherapy, but the therapeutic outcomes are limited, and prognosis remains poor. Therefore, there is a critical need to understand the pathogenesis of OC, identify biomarkers for early diagnosis and prognosis, and discover new therapeutic targets. Forkhead box M1 (FOXM1), recognized as a pro-oncogenic transcription factor (TF), is notably overexpressed in various malignancies, including OC. Research indicates that increased levels of FOXM1 correlate significantly with OC's aggressive behaviors such as proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), and resistance to chemotherapy. These observations suggest that FOXM1 could potentially function as both a biomarker and a therapeutic target, facilitating the early detection and treatment of OC.
Keywords: ovarian cancer, FoxM1, Cancer biomarkers, Early detection, cancer diagnosis
Received: 24 Mar 2025; Accepted: 03 Jun 2025.
Copyright: © 2025 檀, Guo, zheng and Xiong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jun Xiong, Second Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, China
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