REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1598934
This article is part of the Research TopicFormation of Immunological Niches in Tumor Microenvironments: Mechanisms and Therapeutic PotentialView all 27 articles
Application and recent advances in conventional biomarkers for the prognosis of papillary thyroid carcinoma
Provisionally accepted
- Chongqing Health Center for Women and Children, Chongqing, China
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Cancer remains one of the most common and deadliest diseases worldwide. Among endocrine neoplasms, the incidence of thyroid malignancies has been rising in recent years. Papillary thyroid carcinoma (PTC), the most frequently observed histological subtype of thyroid cancer (THCA), typically yields favorable clinical outcomes for affected individuals. However, this has raised concerns about the overdiagnosis and underdetermination of the prognostic factors in PTC cases. As a result, researchers now advocate for patient stratification and tailored therapeutic approaches for PTC cases, with the goal of minimizing unnecessary surgical procedures and radioiodine treatments. These treatments can lead to clinical complications and impose avoidable physiological and psychological stress on patients. Multiple prognostic biomarkers have been identified for PTC, which play a critical role in predicting outcomes and informing treatment decisions. This review examines both established molecular tools and recent advancements in the determination of prognosis in in papillary thyroid carcinoma.
Keywords: Papillary thyroid carcinoma, BRAF V600E, TERT, Ras, CD147, Tumor Microenvironment，ctDNA，microRNA
Received: 24 Mar 2025; Accepted: 30 Apr 2025.
Copyright: © 2025 Chen, Li, Li, Zou and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanlin Chen, Chongqing Health Center for Women and Children, Chongqing, China
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