REVIEW article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1599608
Exosomes in lung cancer: A role in early diagnosis
Provisionally accepted
- 1Wuhan Kindstar Medical Laboratory Co., Ltd.,, Wuhan, China
- 2Tianjin university chest hosipital, Tianjin, China
- 3Tianjin Chest Hospital, Tianjin, Tianjin Municipality, China
- 4Kindstar Global Precision Medicine Institute, Wuhan, China
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Lung cancer is the most prevalent and deadly malignant tumor in the world. Traditional treatment methods rely on histopathological analysis of cancer cells obtained through tissue biopsies, which carry risks due to their invasive nature. Thus, there is an urgent need to identify effective and non-invasive early screening methods for lung cancer. Exosomes, a crucial element of liquid biopsies, have emerged as a promising alternative due to their non-invasive collection, convenience and cost-effectiveness in diagnosing lung cancer. Research has underscored the role of exosomes in lung cancer invasion, metastasis, immune regulation, and the tumor microenvironment. Furthermore, the contents of exosomes, such as miRNAs, lncRNAs, circRNAs, and proteins, demonstrate considerable potential for the early diagnosis of lung cancer. This article provides a comprehensive review of the role and application of exosomes as liquid biopsy markers for early diagnosis of lung cancer, emphasizing their promise in improving patient outcomes through earlier detection and intervention.
Keywords: lung cancer, Exosomes, early diagnosis, biomarkers, liquid biopsy
Received: 25 Mar 2025; Accepted: 26 May 2025.
Copyright: © 2025 Zhou, Ma, Li, Xu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yijun Xu, Tianjin university chest hosipital, Tianjin, China
Lingling Zhao, Wuhan Kindstar Medical Laboratory Co., Ltd.,, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.