CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1600376
Long-term survival with multidisciplinary treatment in metastatic sarcomatoid renal cell carcinoma：A case report and literature review
Provisionally accepted
- Qilu Hospital of Shandong University (Dezhou), Dezhou, China
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Background: Sarcomatoid transformation in renal cell carcinoma, termed sarcomatoid renal cell carcinoma (SRCC), is pertaining to aggressive behaviour and unfavorable prognosis. The presence of sarcomatoid differentiation implies a therapeutic challenge due to the response to existing systemic therapies, advances in drugs with Immune checkpoint inhibitor (ICI) therapies could improve response rates.The case reported is about a middle-aged female, who was diagnosed with multiple metastatic SRCC and treated with pembrolizumab plus axitinib as first-line therapy, transarterial chemoembolization, and nephrectomy combined. Our patient eventually in this present case achieved complete remission, but presented with severe colitis symptoms. After the cessation of pembrolizumab and axitinib therapies for one year, her colitis symptoms gradually ameliorated, with no evidence of recurrence or metastasis observed within that period. Her survival period has extended beyond two and a half years. Conclusion ： Metastatic sarcomatoid renal cell carcinoma has very poor prognosis, with a survival of <1 year despite systemic therapy. In this present case, our patient achieved long-term survival following multidisciplinary treatment, a rare incidence worthy of report.
Keywords: sarcomatoid renal cell carcinom(SRCC), Renal cell carcinoma (RCC), Pembrolizumab, axitinib, Nephrectomy
Received: 26 Mar 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Li, Wang, Meng and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Honglu Liang, Qilu Hospital of Shandong University (Dezhou), Dezhou, China
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