SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Breast Cancer
Association Between Hysterectomy for Benign Indications and the Risk of Breast Cancer: a systematic review and meta-analysis
Provisionally accepted
- 1Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing Municipality, China
- 2Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China
- 3Graduate School of Beijing University of Chinese Medicine, Beijing, China
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Objectives: To determine the association between hysterectomy performed for benign indications and the risk of developing BC. Methods: A literature search was conducted in PubMed, Embase, and the Cochrane Library from database inception up to December 11, 2024. Eligible studies were observational design. Relative ratios (RRs) and 95% confidence intervals (CIs) were pooled using a random-effects model, I² was used to assess the heterogeneity between studies. Results: This meta-analysis included 12 studies, consisting of 4 case-control studies and 8 cohort studies. The pooled analysis of case-control studies indicated that hysterectomy reduced the risk of BC (RR= 0.839, 95% CI: 0.707-0.995, P = 0.043, I2= 81.661%). However, the pooled analysis of cohort studies did not observe a significant association between hysterectomy and the occurrence of BC (RR= 0.981, 95% CI: 0.927-1.037, P = 0.495, I2 = 60.319%). Conclusions: The present study reveals a protective effect of hysterectomy on the occurrence of BC in case-control studies. However, more studies, especially cohort studies, are needed to elucidate the potential beneficial effects of hysterectomy on the development of BC.
Keywords: Hysterectomy, breast cancer, risk, Meta-analysis, Systematic review
Received: 26 Mar 2025; Accepted: 03 Nov 2025.
Copyright: © 2025 Liu, Lu, Yang and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Liu, dr.liujie@163.com
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