SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1601261
Bibliometric analysis combined with Visualization on Universal Trends and Hot Topics of LOX family in Human Diseases: 1995 to 2025
Provisionally accepted
Tingting Yang1,2
Wenxuan Zhou1,2Ning Zhang1,2Zhenyu Tian1,2Heming Wang1,2Heng Li1,2Yuyan Feng1Yunguang Chen1
Zhen Wang1*- 1Jiangnan University, Wuxi, China
- 2Wuxi Medical College, Jiangnan University, Wuxi, Jiangsu Province, China
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Lysyl oxidase (LOX) is crucial for modifying collagen and elastin, thereby preserving tissue integrity. Aberrant LOX activity has been associated with a multitude of health disorders, including cutaneous, pulmonary, fibrotic, cardiovascular diseases, and cancer. In cancer, LOX can either promote or inhibit tumor development, and its expression level is closely correlated with patient prognosis. This research utilized data retrieved from the Web of Science Core Collection on May 30, 2025. The search strategies were crafted to target LOX -related terms while excluding irrelevant ones, and the data were limited to English -language articles. Over the past 30 years, 9261 LOX -related publications were identified. The number of articles exhibited an upward trend, especially in the past decade. The United States, China, and Japan were the leading countries in terms of publication output, with institutions like Harvard University and Boston University being highly productive. By leveraging VOSviewer and CiteSpace, "cancer" and "fibrosis" were pinpointed as key research hotspots. There were 983publications on LOX in fibrosis research and 2490 in cancer research, both showing growth trends. Keyword network analysis revealed the diverse functions of LOX, and the most-cited references predominantly focused on its role in the tumor microenvironment. This study presents an overview of LOX -related research. Comprehending the mechanisms of LOX can offer valuable perspectives on tumor biology. Future research on LOX -extracellular matrix interactions and associated gene pathways may lead to the development of novel diagnostic and treatment modalities targeting LOX.
Keywords: bibliometric analysis, lysyl oxidase, Diseases, Fibrosis, Cancer, Extracellular Matrix
Received: 27 Mar 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Yang, Zhou, Zhang, Tian, Wang, Li, Feng, Chen and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhen Wang, Jiangnan University, Wuxi, China
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