ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Imaging and Image-directed Interventions
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1601817
This article is part of the Research TopicCurrent Challenges and Future Perspectives in Neuro-Oncological ImagingView all 4 articles
Imaging characteristics of central neurocytomas according to Ki-67 proliferation index
Provisionally accepted
- 1Affiliated Hospital of Yangzhou University, Yangzhou, China
- 2Affiliated Yantai Yuhuangding Hospiatal of Qingdao University, Yantai, China
- 3Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
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Purpose: To evaluate the imaging characteristics of central neurocytoma (CN) with different Ki-67 indices and reveal its biological behavior.Sixty-nine cases of intraventricular CN confirmed by histopathology were collected retrospectively. According to Ki-67 indices, they were divided into CNs with high Ki-67 (30 cases) and CNs with low Ki-67 (39 cases). Their clinical and imaging findings were compared and analyzed.Results: Compared to CNs with low Ki-67, CNs with high Ki-67 were larger (P < 0.001) and more solid (P = 0.019). Restricted diffusion (P = 0.020), CT hyperdensity (P < 0.001), abnormal vessels (P = 0.018), and marked MRI enhancement (P < 0.001) were more common in CNs with high Ki-67.: Different Ki-67 indices could affect the imaging characteristics of CNs. Tumor size, radiologic solidity, abnormal vessels, and marked MRI enhancement suggested CNs with high Ki-67. Combining these imaging characteristics and Ki-67 indices offered meaningful insights into their clinical diagnosis and biological behavior.
Keywords: Central neurocytoma, Ki-67, MRI, CT, Imaging diagnosis
Received: 28 Mar 2025; Accepted: 19 May 2025.
Copyright: © 2025 Zhang, Liu, Li, Ran and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei Li, Affiliated Hospital of Yangzhou University, Yangzhou, China
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