CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1602250
Ectopic Breast Fibroadenoma of the Vulva:a case report
Provisionally accepted
- Department of Pathology, Mianyang Central Hospital, Mianyang, China
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Background :Vulvar ectopic breast fibroadenoma (EBF) is an exceptionally rare benign neoplasm that lacks distinctive clinical or radiological features, rendering pre-operative differentiation from other vulvar masses challenging. Definitive diagnosis requires histopathological confirmation. Two non-exclusive histogenetic hypotheses have been proposed: (1) derivation from ectopic breast tissue along the embryonic "milk line," and (2) origin from hormonally responsive anogenital mammary-like glands with latent potential for benign or malignant transformation. Case Presentation: A 41-year-old woman presented with an incidentally discovered, slowly enlarging, painless right vulvar mass. Ultrasonography revealed a well-circumscribed hypoechoic nodule. Complete surgical excision was performed, and histopathological evaluation—including immunohistochemistry for estrogen receptor, progesterone receptor, GATA3, and p63 — confirmed ectopic breast fibroadenoma. No recurrence was detected at 3-month follow-up. Conclusion: Despite its rarity, vulvar EBF must be considered in the differential diagnosis of vulvar masses in reproductive-age women. En-bloc excision is curative; however, long-term surveillance is warranted to monitor for hormone-driven recurrence or malignant evolution.
Keywords: ectopic, breast fibroadenoma, Vulva, diagnosis, Treatment
Received: 29 Mar 2025; Accepted: 29 Aug 2025.
Copyright: © 2025 He, Xie, Ji, Shi, He and Xue. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lei Xue, Department of Pathology, Mianyang Central Hospital, Mianyang, China
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