CASE REPORT article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1602774
An Exceptional Oncological Enigma: Primary Renal Ewing Sarcoma in a Clinical Context-A case report
Provisionally accepted
- 1Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
- 2Urology Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
- 3Department of Radiology, Faculty of Medicine, Universiti Kebangsaan Malaysia,, Kuala Lumpur, Malaysia
- 4Department of Pathology, Hospital Picaso, Petaling Jaya, Malaysia, Selangor, Malaysia
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Primary renal Ewing sarcoma/Primitive neuroectodermal tumor (PNET) is a very rare and aggressive malignant tumor. We report a case of a young adult who presented with painless hematuria and acute urinary retention and was subsequently diagnosed with localized left renal Ewing sarcoma following robotic-assisted retroperitoneal partial nephrectomy. Histopathology revealed a tumor composed of nests and lobules of monotonous tumor cells with round nuclei, indistinct nucleoli and scanty cytoplasm, associated with a vascular-rich to hyalinized stroma and fibrillary neural matrix. Moderate nuclear pleomorphism, scattered necrosis, and pseudorosette formation were noted. Immunohistochemical studies demonstrated tumor cell positivity for CD99 and CD117. Patient was subjected to chemotherapy. Early diagnosis and multimodality treatment play an important role in improving survival rate.
Keywords: renal Ewing sarcoma, Primitive neuroectodermal tumor (PNET), laparoscopic nephrectomy, chemotherapy, case report
Received: 30 Mar 2025; Accepted: 14 Jul 2025.
Copyright: © 2025 TAN, Fam, Iqbal Hussain and Lee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xeng Inn Fam, Urology Unit, Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
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