CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1602987
A rare case report on esophageal squamous cell carcinoma metastatic to the pancreas
Provisionally accepted
- 1Huntsman Cancer Institute, School of Medicine, The University of Utah, Salt Lake City, United States
- 2Department of Pathology, The University of Utah, Salt Lake City, Utah, United States
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Pancreatic metastasis of esophageal squamous cell carcinoma is extremely rare. We describe a case of man aged 66 years who presented with a 3-month history of dysphagia. Esophagogastroduodenoscopy demonstrated an esophageal mass.Additional asymptomatic solitary lung and pancreatic masses were observed in the staging work-up for esophageal cancer, concerning for metastatic versus synchronous primary malignancy. Computed Tomography guided needle biopsy of the lung and pancreatic masses was performed. Given the difficulty to definitively histologically confirm both the lung and the pancreatic masses were metastasis from the primary esophageal cancer, next generation sequencing and tumor origin testing was performed. Tumor origin testing was indeterminate with the molecular profile inconclusive. Treatment was initiated with chemotherapy and immunotherapy.
Keywords: esophageal cancer, Squamous cell carcinoma, Pancreatic metastasis, Tumor origin identification, rare causes of stroke
Received: 30 Mar 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Bhatti, Rogers, Witt, Nevala-Plagemann and Patterson-Fortin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jeffrey Patterson-Fortin, Huntsman Cancer Institute, School of Medicine, The University of Utah, Salt Lake City, United States
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