CASE REPORT article
Front. Oncol.
Sec. Cardio-Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1605692
Cardiac Myxomas and Carney Complex: A Case of Recurrent Embolic Strokes and Intracranial Tumor Growth
Provisionally accepted- 1Adrenal Unit, Department of Endocrinology and Metabolism, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
- 2Laboratory of Hormones and Molecular Genetics, Laboratory of Medical Research, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
- 3Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, School of Medicine, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, United States
- 4Department of Clinical Oncology, Institute of Cancer of São Paulo, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
- 5Division of Neurosurgery Oncology, Institute of Cancer of São Paulo, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
- 6Heart Institute (InCor), São Paulo, Sao Paulo, Brazil
- 7Division of Endocrine Oncology, Institute of Cancer of São Paulo, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil
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Cardiac myxomas, though rare, are the most common benign cardiac tumors and may be associated with Carney Complex (CNC). Patients with CNC are at increased risk of developing recurrent myxomas, which can lead to severe complications. We report a case of a 46-year-old woman with CNC and recurrent cardiac myxomas who developed multiple embolic strokes and cerebral aneurysms. Following two hemorrhagic strokes, neuroimaging and biopsy revealed a well-differentiated myxoid neoplasm in the brain parenchyma. Genetic analysis revealed a germline pathogenic PRKAR1A variant, along with loss of heterozygosity (LOH) at chromosome 17q24.2 in the cardiac myxoma, but not in the brain lesion. This case challenges the conventional understanding of cardiac myxomas as strictly benign, suggesting they may exceptionally exhibit distant proliferative behavior, likely through mechanical dissemination and subsequent growth in the brain. Although embolic events are common in cardiac myxomas, the capacity of tumor cells to implant and proliferate in extracardiac sites remains poorly understood. Our findings underscore the importance of maintaining a high index of suspicion for neurological complications in patients with cardiac myxomas, particularly in the setting of CNC. Further investigation is essential to elucidate the mechanisms driving this behavior and to optimize management strategies in similar cases.
Keywords: brain tumor, Emboli, cardiac myxoma, Carney Complex, case report
Received: 03 Apr 2025; Accepted: 06 Jun 2025.
Copyright: © 2025 Kuhn, Lerario, Morais, Iglesio, Ramires, Hoff, Latronico, Mendonca, Almeida and Fragoso. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Aliny Weber Kuhn, Adrenal Unit, Department of Endocrinology and Metabolism, Clinical Hospital, Faculty of Medicine, University of São Paulo, São Paulo, 05403-000, São Paulo, Brazil
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