ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1606286
This article is part of the Research TopicEnhancing outcomes in colorectal cancer: Multidisciplinary approaches to therapy and pain managementView all 7 articles
Renal Dysfunction as a Predictor of Recurrence and Prognosis in Colorectal Cancer
Provisionally accepted
- The Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Purpose： This study explores the relationship between eGFR and recurrence and prognosis in patients with colorectal cancer (CRC).Methods: Patients first diagnosed with CRC at Zhengzhou People's Hospital between 2018 and 2021 with a median follow-up of 715 days were studied. Demographics, disease characteristics, kidney function were collected. Associations between eGFR and clinical prognosis were assessed using multivariate Cox proportional hazards regression models. The impact of eGFR on the recurrence was evaluated by logistic and Poisson regression models. Odds ratios are reported for associations between eGFR and recurrence and prognosis. Stratified analyses and restricted cubic splines (RCS) were used to evaluate the results between subgroups and nonlinear relation between eGFR and the prognosis and recurrence of patients with CRC.Results: 93 CRC patients completed the study. Poor renal filtration function and impaired urine concentrating ability were found in CRC patients. Multivariate analysis showed that eGFR was an independent predictor of clinical prognosis (eGFR ＜ 90 mL/min OR=4.248, 95% CI [1.061-17.003], P=0.041, the eGFR of 90-110 mL/min OR=5.087, 95% .400], P=0.022) when using the eGFR ≥ 130 mL/min as the reference. Multivariate analysis showed that eGFR (OR=0.964, 95% CI [0.933-0.997], P=0.032) was an independent protective factor influencing recurrence of CRC patients. RCS analysis showed that the relationship between eGFR and prognosis of CRC patients had no significant nonlinear correlation (P for nonlinear=0.19), the relationship between eGFR and recurrence was non-linear (P for nonlinear＜0.001).Conclusions: CRC patients exhibited kidney dysfunction, and eGFR is identified as an independent predictor of disease recurrence and prognosis.
Keywords: colorectal cancer, Kidney function, EGFR, Recurrence, Clinical prognosis
Received: 05 Apr 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Ren, Zhu, Li and Xia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuekang Ren, The Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Yunzhan Xia, The Fifth Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.