ORIGINAL RESEARCH article
Front. Oncol.
Sec. Pediatric Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1606627
Contemporary Epidemiological Landscape of Pediatric non-Hodgkin Lymphoma: A Global Burden of Disease Analysis
Provisionally accepted
- 1Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
- 2Chengdu Shuangliu Hospital of Traditional Chinese Medicine, Chengdu, China
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This study evaluated the distribution characteristics, influencing factors, and future trends of non-Hodgkin lymphoma (NHL) burden in children and adolescents globally from 1990 to 2021.Using data from the Global Burden of Disease Study database, researchers employed multiple analytical methods including Joinpoint regression, age-period-cohort analysis, decomposition analysis, frontier analysis, health equity analysis, and Bayesian age-period-cohort (BAPC) model.Results showed that in 2021, the global age-standardized prevalence rate was 3.177/100,000, with a disability adjusted life year (DALY) rate of 13.535/100,000. The prevalence demonstrated a fluctuating downward trend during 1990-2021. Age, period, and cohort effects significantly influenced disease patterns. While population growth drove prevalence increase, population aging and epidemiological factors had negative impacts. Disease burden showed a non-linear negative correlation with Socio-demographic Index (SDI). Over the past nearly 30 years, health inequality has intensified, as some African regions have shown relatively low prevalence rates due to limited resource Settings, which have restricted disease diagnosis and reporting, compared with the developed areas with high prevalence. The BAPC model predicted further decrease from 2022-2036. Despite overall decline, significant regional differences and health inequalities persist, suggesting future focus on targeted prevention, optimized resource allocation, and improved treatment.
Keywords: non-Hodgkin lymphoma, Global disease burden, Prevalence, Temporal trend, health inequality
Received: 07 Apr 2025; Accepted: 20 May 2025.
Copyright: © 2025 Luo, Xie, Zhou, Xia, Gao and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaobo Luo, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
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