CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1608291
This article is part of the Research TopicAdvancements in targeted therapies for genitourinary cancersView all articles
Pembrolizumab and Enfortumab Vedotin in Plasmacytoid Urothelial Carcinoma: A Case Series
Provisionally accepted
- University of Kentucky, Lexington, United States
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Plasmacytoid urothelial carcinoma (PUC) is a rare and aggressive histologic subtype of urothelial carcinoma with no well-established treatment. Recently, the combination of pembrolizumab and enfortumab vedotin has become the standard of care for locally advanced and metastatic urothelial carcinoma due to improved survival outcomes in the EV-302 trial, but the number of histological subtypes in this trial is unknown. This case series presents three patients with Stage IV PUC who were treated with the combination of pembrolizumab and enfortumab vedotin. Two of the three patients demonstrated sustained stable disease after eight and ten months of treatment with this combination with manageable adverse effects including rash and colitis. The third patient experienced disease progression to leptomeningeal involvement eight months following initial diagnosis and subsequently succumbed to the disease. These observations support the potential efficacy of pembrolizumab in combination with enfortumab vedotin as a therapeutic option for this aggressive urothelial carcinoma subtype.
Keywords: plasmacytoid, urothelial carcinoma, immune-checkpoint inhibitors, Antibody drug conjugate, Pembrolizumab, enfortumab vedotin. (Min
Received: 08 Apr 2025; Accepted: 12 Aug 2025.
Copyright: © 2025 Goggans, Allison, Hensley and Myint. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Susanna Goggans, University of Kentucky, Lexington, United States
Zin W Myint, University of Kentucky, Lexington, United States
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