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ORIGINAL RESEARCH article

Front. Oncol.

Sec. Gynecological Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1608386

This article is part of the Research TopicOptimizing Radiotherapy for Cervical Cancer Efficacy Toxicity and Brachytherapy IntegrationView all 11 articles

Enhancing Cervical Cancer Diagnosis with Ensemble Learning and Shark Optimization Algorithm: Comparative Study of CT and MRI in Cervical Cancer Diagnosis

Provisionally accepted
Eman  Hussein AlshdaifatEman Hussein Alshdaifat1Amer  Mahmoud SindianiAmer Mahmoud Sindiani2Salem  AlhatamlehSalem Alhatamleh1Hamad  Yahia Abu MhannaHamad Yahia Abu Mhanna3Rola  MadainRola Madain2Mohammad  AminMohammad Amin1Majd  MalkawiMajd Malkawi2Ameera  JaradatAmeera Jaradat1Hanan  Fawaz AkhdarHanan Fawaz Akhdar4*Hasan  Gharaibeh‬‏Hasan Gharaibeh‬‏5Fatimah  MaasheyFatimah Maashey4Latifah  AlghulayqahLatifah Alghulayqah4
  • 1Yarmouk University, Irbid, Jordan
  • 2Jordan University of Science and Technology, Irbid, Irbid, Jordan
  • 3Isra University, Amman, Amman, Jordan
  • 4Imam Muhammad ibn Saud Islamic University, Riyadh, Saudi Arabia
  • 5King Hussein Medical Center, Amman, Amman, Jordan

The final, formatted version of the article will be published soon.

Cervical cancer, one of the most common female cancers, can be detected with computed tomography (CT) and magnetic resonance imaging (MRI). Computer-aided diagnosis (CAD) methods based on artificial intelligence have been widely explored to improve traditional screening methods for cervical cancer detection. This study aims to compare the accuracy of CT and MRI in diagnosing cervical cancer using a novel methodology that combines the Large Vision Model (LVM) and InternImage, which reduces the misclassification of cervical tumors, especially in benign and malignant cases. InternImage (based on InceptionV3) extracts pre-trained deep features, making it more sensitive to tumor-specific patterns. At the same time, LVM focuses on fine-grained spatial features, helping to classify early changes in cervical pathology. In the Shark Optimization Algorithm (SOA), the procedure dynamically selects the optimal weight parameter, avoiding overreliance on a single model. This application improves generalization across different CT and MRI datasets. The performance of the proposed model is evaluated on two new datasets, KAUH-CCTD and KAUH-CCMD, collected from King Abdullah University Hospital (KAUH) in Jordan. The proposed model classified images into three categories: benign, malignant, and normal. The proposed model achieved the best performance in diagnosing CT images, with an accuracy of 98.49%, while achieving an accuracy of 92.92% in diagnosing MRI images. CT imaging, especially MRI, can detect tumor extension into the cervical stroma, which could change treatment approaches. Additionally, imaging plays a crucial role in monitoring treatment and patient progress to detect early disease relapses.

Keywords: gynecologic oncology, cervical cancer, Classification Medical Image, deep learning, computer aided diagnosis, MRI image, CT image

Received: 08 Apr 2025; Accepted: 25 Sep 2025.

Copyright: © 2025 Alshdaifat, Sindiani, Alhatamleh, Abu Mhanna, Madain, Amin, Malkawi, Jaradat, Akhdar, Gharaibeh‬‏, Maashey and Alghulayqah. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Hanan Fawaz Akhdar, hfakdar@imamu.edu.sa

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