REVIEW article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1609832
The Impact of Estrogen on Benign Breast Tumors and Exploration of Recurrence Mechanisms
Provisionally accepted
- 1Department of Breast and Thyroid Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
- 2Thyroid and Breast Surgery Department, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
- 3School of Pediatrics, Guangzhou Medical University, Guangzhou, China
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Benign breast tumors are among the most common breast diseases affecting women, with their pathogenesis closely linked to hormonal influences, particularly estrogen. This review offers a comprehensive overview of the mechanisms through which estrogen affects benign breast tumors and examines the role of estrogen in tumor cell growth, proliferation, and apoptosis.Furthermore, this review explores the recurrence mechanisms of benign breast tumors, analyzing factors such as hormone dependence, microenvironmental influences, and genetic susceptibility.By generating relevant literature, this article aims to offer new insights into clinical treatment and prevention strategies aimed at managing benign breast tumors.
Keywords: estrogen, Benign breast tumors, recurrence mechanisms, Hormone dependence, microenvironment
Received: 11 Apr 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Fan, Wang, Liu, Yu, Li and Teng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuan Teng, Department of Breast and Thyroid Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.