REVIEW article
Front. Oncol.
Sec. Cancer Genetics
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1611007
Interactions between ALKBH5 and Reader proteins in tumors: Functions and Molecular mechanisms
Provisionally accepted
- 1Hunan University of Chinese Medicine, Changsha, China
- 2Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
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RNA methylation modifications are widespread in eukaryotes and prokaryotes, with N6methyladenosine (m6A) methylation being the most prevalent internal modification in eukaryotic mRNA and having become a prominent focus of tumor research in recent years. Up to now, substantial evidence has suggested that the dysregulated RNA demethylase ALKBH5 can interact with m6A reader proteins to modulate a wide range of mRNA biological progress, including mRNA shearing, export, metabolism, and stability, ultimately influencing tumorigenesis and development.To deeply understand the regulatory roles of ALKBH5 and reader proteins in tumor progression, this review aims to summarize the structures of ALKBH5 and reader proteins, as well as their cooperative regulatory mechanisms that affect the occurrence and development of tumors originating from different systems. Furthermore, the potential applications of targeting ALKBH5 and reader proteins in antitumor drug development are summarized, hoping to provide a strong basis for advancing antineoplastic research in the future.
Keywords: M6A, ALKBH5, Reader proteins, tumor, m6A inhibitors
Received: 13 Apr 2025; Accepted: 11 Aug 2025.
Copyright: © 2025 Ou, Liu, Yu, He, Gao, Chen, Chen and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xia Chen, Department of Orthopaedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China
Huai Tao, Hunan University of Chinese Medicine, Changsha, China
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