CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1612716
This article is part of the Research TopicCutting-Edge Strategies in Screening, Prevention, and Treatment in Gynaecologic OncologyView all 16 articles
A Rare Case Report of Uterine Carcinosarcoma with Bilateral Ovarian Brenner
Provisionally accepted
- Department of Obstetrics and Gynecology, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, Liaoning Province, China
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Uterine carcinosarcoma is a rare, highly aggressive malignancy characterized by both carcinomatous and sarcomatous components. Brenner tumors of the ovary are uncommon epithelial neoplasms, usually benign but occasionally coexisting with other pathologies. The co-occurrence of these two entities is extremely rare and poses diagnostic and therapeutic challenges.We report a case of a 58-year-old female presenting with scant yellowish vaginal discharge. Imaging studies revealed an intrauterine mass. Histopathological analysis of curettage specimens confirmed endometrial malignancy. The patient underwent radical surgical resection followed by histopathological and immunohistochemical analysis.Histopathology confirmed uterine carcinosarcoma comprising high-grade endometrial adenocarcinoma and pleomorphic sarcoma with chondrosarcoma differentiation. Bilateral ovarian Brenner tumors were also identified. Given the aggressive nature of carcinosarcoma, the patient was referred for adjuvant therapy.This case highlights the importance of prompt pathological evaluation in atypical gynecologic presentations. Early diagnosis through histopathology and immunohistochemistry is crucial for managing rare and aggressive tumors such as uterine carcinosarcoma, particularly when coexisting with other uncommon neoplasms like Brenner tumors. Multidisciplinary care and individualized treatment plans are essential for optimizing outcomes.
Keywords: Uterine carcinosarcoma, Brenner Tumor, case report, Immunohistochemistry, multidisciplinary care
Received: 16 Apr 2025; Accepted: 08 Aug 2025.
Copyright: © 2025 Wan, Bi, Xin and Qiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chong Qiao, Department of Obstetrics and Gynecology, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, 110004, Liaoning Province, China
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