ORIGINAL RESEARCH article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1613346
Association between Advanced Lung Cancer Inflammation Index and Distant Metastasis in Breast Cancer: A Retrospective Cohort Study
Provisionally accepted
- 1Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, China
- 2Guangxi Medical University Cancer Hospital, Nanning, China
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This study aims to assess the relationship between the Advanced Lung Cancer Inflammation Index (ALI) and the risk of distant metastasis in breast cancer. While ALI is commonly used to evaluate the prognosis of lung cancer patients, its application in breast cancer and its correlation with distant metastasis are not well understood. Therefore, this study explores the potential of ALI as a predictor of distant metastasis in breast cancer patients.This retrospective study included 348 breast cancer patients, of whom 163 had distant metastasis.Patient demographic information, tumor characteristics, and ALI values were collected.Multivariate regression analysis was used to adjust for confounding factors, and dose-response analysis was performed to investigate the relationship between ALI and the risk of distant metastasis. The optimal ALI cutoff value was determined, and its predictive performance was evaluated.The analysis showed that patients with lower ALI had a significantly higher risk of distant metastasis. Adjusted multivariate analysis revealed that for every one interquartile range (IQR) increase in ALI, the risk of distant metastasis in breast cancer decreased by 31% (OR=0.69, 95% CI 0.58-0.81). Dose-response analysis indicated a linear relationship between ALI and metastasis risk. The optimal ALI cutoff value was identified as 36.39 using the Youden index, with an area under the ROC curve (AUC) of 0.605, indicating moderate predictive power of ALI for distant metastasis in breast cancer.Lower ALI is significantly associated with an increased risk of distant metastasis in breast cancer.
Keywords: breast cancer, advanced lung cancer inflammation index (ALI), Distant metastasis (DM), prognostic biomarker, Retrospective cohort study
Received: 17 Apr 2025; Accepted: 30 Jul 2025.
Copyright: © 2025 Luan, Ren, Zhang, Zhang, Liang, Liang, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yukun Liu, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, Qingdao, China
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