ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1613423
This article is part of the Research TopicCommunity Series in Post-Translational Modifications of Proteins in Cancer Immunity and Immunotherapy, Volume IVView all 3 articles
Lactylation-related gene signatures identify glioma molecular subtypes with prognostic, immunological, and therapeutic implications
Provisionally accepted
- Fuyang Traditional Chinese Medicine Hospital, Fuyang, China
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Lactic acid is a by-product of energy metabolism and a signaling molecule that influences tumor progression by regulating immune cell function, angiogenesis, and epigenetic modifications. In this study, 17 lactylation-related prognostic genes were identified through the analysis of TCGA-GBM data. Using non-negative matrix factorization (NMF), two GBM subtypes based on lactylation-related genes (LRGs), termed GBM1 and GBM2, were identified. Survival analysis revealed that the overall survival (OS) of the GBM1 group was significantly lower than that of GBM2 group. Furthermore, notable differences were observed in the expression of key GBM-associated molecular markers between the two subtypes. Tumor microenvironment (TME) analysis demonstrated distinct immune landscapes and genomic characteristics between GBM1 and GBM2. The GBM1 group exhibited higher immune cell infiltration and immune function scores compared to GBM2.Drug sensitivity analysis further revealed differences in response to chemotherapy and targeted therapies between the two subtypes. In vitro data demonstrated that LCP1 knockdown suppressed cell proliferation and invasion, and promoted apoptosis in glioma cells. In conclusion, our study systematically uncovers the significant role of LRGs in GBM molecular subtyping, prognosis evaluation, and therapeutic guidance.These findings offer new insights and potential strategies for the personalized treatment of GBM.
Keywords: Glioblastoma, lactylation, subtype, prognosis, Infiltration
Received: 17 Apr 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Tang, Zhang, Tang, Yuan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenwen Wang, Fuyang Traditional Chinese Medicine Hospital, Fuyang, China
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