REVIEW article
Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1614484
Bibliometrics and Scientometrics Analysis of Exosomes Relevance in Hepatocellular Carcinoma(2014-2024)
Provisionally accepted
- 桂林医科大学第二附属医院, 广西桂林, China
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BACKGROUND: Exosomes have emerged as pivotal players in the pathogenesis, progression, and treatment of hepatocellular carcinoma (HCC), establishing them as a major research focus in recent years. This bibliometric analysis maps the knowledge evolution and quantifies research trends in exosome-associated HCC studies from 2014 to 2024. METHODS: We retrieved relevant publications (2014-2024) from the Web of Science Core Collection (WoSCC) database and conducted bibliometric analyses using CiteSpace, VOSviewer, and R software. RESULTS:The analysis encompassed 1,120 publications (714 research articles and 406 reviews), originating from 60 countries/regions and 4,035 institutions, published in 388 journals, and authored by 6,989 authors.China emerged as the most productive country, followed by the United States. The most prolific journals were the International Journal of Molecular Sciences and Frontiers in Oncology, while Fudan University ranked as the most productive institution.Trend analysis indicates that future HCC exosome research will concentrate on: the development and application of exosomes as HCC biomarkers, optimizing exosomes as drug delivery vehicles, investigating tumor treatment resistance, and exploring exosome-mediated immunotherapeutic strategies for HCC to facilitate their clinical application. CONCLUSION: Current evidence demonstrates that the field of HCC exosome research is in a phase of rapid development, with its potential in both basic research and clinical translation continually being explored. Through bibliometric analysis, this study identifies key trends and emerging directions in HCC exosome research from 2014 to 2024, offering insights into current research priorities and potential innovations.
Keywords: Exosomes, Hepatocellular Carcinoma, bibliometric analysis, Research trends, hotspot
Received: 19 Apr 2025; Accepted: 18 Aug 2025.
Copyright: © 2025 Wu, Lu, Guo, Li and Ou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Minglin Ou, 桂林医科大学第二附属医院, 广西桂林, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.