ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1614743
This article is part of the Research TopicCommunity Series in Immunological Precision Therapeutics: Integrating Multi-Omics Technologies and Comprehensive Approaches for Personalized Immune Intervention: Volume IIView all 16 articles
Association of visceral obesity indicators with prostate cancer: a cross-sectional study from Xinjiang
Provisionally accepted
- 1Xinjiang Medical University, Ürümqi, China
- 2Department of Urology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
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Background: Prostate cancer (PCa) is a common malignancy among men worldwide, and its risk is strongly associated with obesity, especially visceral obesity. Visceral obesity has been assessed by the visceral adiposity index (VAI), cardiometabolic index (CMI), and lipid accumulation product (LAP), but their associations with PCa remain underexplored. This study investigated the relationship between these visceral obesity indicators and PCa risk. Methods: Data for this cross-sectional study were obtained from the First Affiliated Hospital of Xinjiang Medical University from 2022-2023, and 730 participants were screened for the study. A total of 102 PCa patients were included as the PCa group and 102 healthy individuals as the control group using propensity score matching (PSM). We collected anthropometric data (height, weight, waist circumference) and blood biochemical parameters from participants to calculate the VAI, CMI and LAP. These indicators' association and predictive efficacy with PCa were assessed by logistic regression, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curve analysis. The robustness of these results was further examined through sensitivity analyses. Results: VAI, CMI, and LAP were higher in the PCa group than in the control group (P<0.05). Logistic regression models showed that VAI, CMI, and LAP were positively associated with PCa. This association of VAI and CMI shows robustness in sensitivity analysis. Compared with the first quartile (Q1), the fourth quartile's (Q4) VAI, CMI and LAP were linked to an increased risk of
Keywords: prostate cancer, visceral obesity indicators, Cardiometabolic index, Lipid accumulation product, visceral adiposity index
Received: 19 Apr 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Cai, Guan, Xiao, An and Tao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Hengqing An, Department of Urology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China
Ning Tao, Xinjiang Medical University, Ürümqi, China
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