CASE REPORT article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1615256
This article is part of the Research TopicEnhancing Prostate Cancer Diagnosis: Biomarkers and Imaging for Improved Patient OutcomesView all 19 articles
A rare case of cervical lymph node metastasis from prostate cancer suspicious for combined lung cancer: A case report
Provisionally accepted
- Dalian University, Dalian, China
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Cervical lymph node metastasis as the initial manifestation of prostate cancer is uncommon, and the diagnostic and therapeutic process becomes considerably more complex when primary lung malignancy is also suspected. Immunohistochemical techniques are critical in diagnosing multiple primary malignancies, particularly when histopathologic access is limited. We report a 74-year-old male who presented with respiratory symptoms. Computed tomography revealed a 6.4×4.7 cm mass in the upper lobe of the right lung with cervical lymph node metastasis. The initial diagnosis of metastatic adenocarcinoma was established by cervical lymph node biopsy. During follow-up, the patient developed progressive dysuria, and prostate cancer was ultimately confirmed by prostate biopsy. Immunohistochemical (IHC) analysis of the cervical lymph node specimen revealed the following profile: PSA (focally positive, 3+), P504S (diffusely positive, 3+), TTF1 (-), CK7 (-), CK20 (-), Napsin A (-), and P40 (-). This IHC profile definitively established the prostatic origin of the metastatic carcinoma in the cervical lymph node. This case highlights the value of employing therapeutic diagnostic strategies when definitive histopathologic access is challenging and provides insights for managing atypical metastatic prostate cancer and multiple primary cancers.
Keywords: prostate cancer, Cervical lymph node metastasis, Lungcancer, Multiple primary malignancies, case report
Received: 21 Apr 2025; Accepted: 25 Sep 2025.
Copyright: © 2025 周, Du, sun and song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: fanghua song, greentreesfh@163.com
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