REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1616883
A Deep Dive into the Surgical and Pharmacological Considerations of Obesity in Chronic Myeloid Leukemia: A Narrative Review
Provisionally accepted
Rola Ghasoub1*
Basant Elsayed2
Maria Benkhadra1
Giuseppe Nicola Saglio3
Jorge Cortes4Mohamed Elmarasi2Engy Elsayed2Ahmed Adel Elsabagh2Ibrahim Elmakaty2Abdelrahman Elsayed2
Mohamed A Yassin1*- 1National Center for Cancer Care and Research, Doha, Qatar
- 2Hamad Medical Corporation, Doha, Qatar
- 3University of Turin, Turin, Piedmont, Italy
- 4Georgia Cancer Center, Augusta University, Augusta, Georgia, United States
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Obesity complicates the treatment of patients with chronic myeloid leukemia (CML), and bariatric surgery may impact how patients respond to their medications. This review examines the limited research on how obesity and weight loss surgeries affect the effectiveness of tyrosine kinase inhibitors (TKIs), which are commonly used to treat CML. The findings suggest that certain surgeries, like gastric bypass, could reduce drug absorption due to changes in gastric acidity, potentially making treatments less effective. Patients who have had these surgeries may need different dosing strategies for their TKIs and should avoid certain weight loss medications and herbs that can interfere with drug absorption. Careful planning and counseling are essential for patients with CML considering bariatric surgery to ensure they achieve deep remission before the procedure. Overall, a collaborative clinical approach is recommended for managing obesity in CML patients while more research is needed on appropriate dosing and treatment strategies.
Keywords: Obesity, tyrosine kinase inhibitors, Chronic myeloid leukemia, Weight loss pharmacotherapy, Bariatric Surgery, Lifestyle modifications
Received: 24 Apr 2025; Accepted: 26 May 2025.
Copyright: © 2025 Ghasoub, Elsayed, Benkhadra, Saglio, Cortes, Elmarasi, Elsayed, Elsabagh, Elmakaty, Elsayed and Yassin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rola Ghasoub, National Center for Cancer Care and Research, Doha, Qatar
Mohamed A Yassin, National Center for Cancer Care and Research, Doha, Qatar
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