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ORIGINAL RESEARCH article

Front. Oncol.

Sec. Gastrointestinal Cancers: Gastric and Esophageal Cancers

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1619106

This article is part of the Research TopicReal-World Clinical and Translational Research in Gastrointestinal CancersView all 12 articles

Prognostic Value of the Log Odds of Negative Lymph Nodes/T stage ratio (LONT) in Postoperative Esophageal Cancer: A SEER-Based Study

Provisionally accepted
  • Fujian Medical University Union Hospital, Fuzhou, China

The final, formatted version of the article will be published soon.

Surgery remains the primary treatment for patients with esophageal cancer (EC), but postoperative prognosis is often unsatisfactory. We developed an interactive web-based tool to estimate cancer-specific survival (CSS) in patients with T1~3N0~2M0 EC after surgery, based on the log odds of negative lymph nodes/T stage ratio (LONT). A total of 2,221 patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into training and testing sets. Univariate Cox regression analysis revealed that age, sex, T stage, N stage, chemotherapy, and LONT were significantly associated with CSS. ROC curve comparisons using Cox regression and random survival forest (RSF) models showed that LONT outperformed N stage in predictive accuracy, particularly for 1-year CSS. Decision curve analysis (DCA) and calibration curves indicated that the model had high predictive accuracy. Finally, we developed an interactive web-based tool of effectively estimating 1-, 3-, and 5-years CSS and survival trends in postoperative patients with T1~3N0~2M0 EC.

Keywords: esophageal cancer, LONT, RSF, postoperative, SEER

Received: 27 Apr 2025; Accepted: 31 Jul 2025.

Copyright: © 2025 Lin, Chen, Lu, Huang, Han and Kang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Ziyang Han, Fujian Medical University Union Hospital, Fuzhou, China
Mingqiang Kang, Fujian Medical University Union Hospital, Fuzhou, China

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