MINI REVIEW article
Front. Oncol.
Sec. Cancer Immunity and Immunotherapy
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1620501
This article is part of the Research TopicCommunity Series in Immunological Precision Therapeutics: Integrating Multi-Omics Technologies and Comprehensive Approaches for Personalized Immune Intervention: Volume IIView all 17 articles
Mapping the Immunological Landscape and Emerging Immunotherapeutic Strategies in Cervical Cancer: A Comprehensive Review
Provisionally accepted
- 1Clinical Medical College, Southwest Medical University, Luzhou, China
- 2College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
- 3Department of Gynecology, Affiliated Hospital of Southwest Medical University, LuZhou, 646000, China
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Cervical cancer continues to pose a considerable global health challenge, especially in low-and middle-income nations, although progress in screening and vaccine efforts. In recent years, immunotherapy has emerged as a promising treatment option; nevertheless, its efficacy in cervical cancer is constrained by the intricate and heterogeneous tumor immune microenvironment. Reliable biomarkers to predict which patients will benefit from immunotherapy are lacking. The heterogeneity of the immune landscape across patients adds further complexity. This paper offers a thorough examination of the immunological landscape in cervical cancer, highlighting the interactions among tumor cells, immune infiltrates, and stromal elements. Moreover, we investigate how advanced technologies-such as single-cell RNA sequencing, spatial transcriptomics, and multiplex imaging-are transforming our comprehension of immunological heterogeneity and uncovering new therapeutic targets. We seek to delineate present problems and potential pathways in the development of effective, tailored immunotherapies for cervical cancer by integrating genetic analysis with immunological insights.
Keywords: Cervical cancer, tumor immune microenvironment, Immunothearpy, PD-1/PD-L1 signaling pathway, Immune checkpoint
Received: 29 Apr 2025; Accepted: 18 Jun 2025.
Copyright: © 2025 Zhang, Nie, Shao and Guo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xinyi Zhang, Clinical Medical College, Southwest Medical University, Luzhou, China
Wenwen Shao, College of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China
Qian Guo, Department of Gynecology, Affiliated Hospital of Southwest Medical University, LuZhou, 646000, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.