CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1621686
This article is part of the Research TopicInterplay between Environmental Drivers and Genetic or Epigenetic Predispositions on Gastrointestinal Cancer EvolutionView all articles
Primary Hepatic Leiomyosarcoma Concurrent with Early-Stage Lung Adenocarcinoma: A Rare Case Report
Provisionally accepted
- 1Hepatobiliary Surgery, The First People's Hospital of Chenzhou, Chenzhou, China
- 2ultrasound department, Xiangnan College Affiliated Hospital, chenzhou city, China
- 3pathology, The First People's Hospital of Chenzhou, Chenzhou, China
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Primary hepatic leiomyosarcoma (PHL) is an extremely rare malignant mesenchymal tumor, accounting for less than 2% of all primary hepatic malignancies. We report a case of a 46-year-old female who presented with a one-year history of abdominal distension and pain. Imaging revealed a 6×5×4 cm mass in the left hepatic lobe (segments 3/4) and incidentally detected a suspicious pulmonary nodule. Laparoscopic partial left hepatectomy followed by thoracoscopic wedge resection of the left upper lung confirmed the diagnoses of primary hepatic leiomyosarcoma and primary lung adenocarcinoma (cT1aN0M0), respectively. This case highlights the importance of comprehensive diagnostics, immunohistochemical analysis, and multidisciplinary management of rare hepatic tumors, particularly when concurrent malignancies are present. This first reported case of concurrent PHL and primary lung adenocarcinoma provides valuable insights for clinical practice in managing patients with rare hepatic malignancies.
Keywords: Primary hepatic leiomyosarcoma, Lung Adenocarcinoma, Synchronous primary malignancies, Liver Neoplasms, multidisciplinary management
Received: 01 May 2025; Accepted: 11 Jun 2025.
Copyright: © 2025 Peng, xiao, yu and li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weizhong Peng, Hepatobiliary Surgery, The First People's Hospital of Chenzhou, Chenzhou, China
xiaohui xiao, ultrasound department, Xiangnan College Affiliated Hospital, chenzhou city, China
yi yu, Hepatobiliary Surgery, The First People's Hospital of Chenzhou, Chenzhou, China
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