ORIGINAL RESEARCH article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1621841
Persistent cough after segmental resection, An issue that clinicians need to pay more attention to
Provisionally accepted
- 1Zheng zhou university people's hosptial, Zheng Zhou, China
- 2Henan Provincial People's Hospital, Zheng zhou, China
- 3Henan University People's Hospital, Zheng Zhou, China
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Persistent cough after pulmonary resection can significantly impair a patient's quality of life. However, risk factors for persistent cough after pulmonary segmentectomy remain insufficiently described. This study aims to explore the risk factors for persistent cough following pulmonary segmentectomy and to establish a predictive model to guide perioperative management.This retrospective study included 540 patients who underwent thoracoscopic pulmonary segmentectomy at Zhengzhou University People's Hospital from February 2024 to January 2025. Data were divided into training and internal validation cohorts. Multivariate logistic regression analysis was performed using the training cohort to develop a predictive model. Data from 160 patients who underwent thoracoscopic pulmonary segmentectomy at Zhengzhou Seventh People's Hospital from August 2024 to February 2025 were used for external validation. Both validation cohorts were used to evaluate the model's reliability and its impact on patient outcomes.There were no significant differences in the distribution of variables between the training and internal validation cohorts. Tobacco exposure (OR 0.19, 95% CI 0.07-0.49), tumor location (OR 2.36, 95% CI 1.27-4.36), type of surgery (OR 3.70, 95% CI 2.18-6.29), vagus nerve injury (OR 2.15, 95% CI 1.23-3.76), and drainage duration (OR 1.48, 95% CI 1.29-1.70) were identified as independent risk factors for persistent cough after surgery. The predictive model derived from multivariate analysis demonstrated high diagnostic value (AUC = 0.80), and the Hosmer-Lemeshow test indicated good model fit (P = 0.818). Both internal and external validation analyses confirmed the model's reliability and substantial net benefit for patients.Persistent cough is a common postoperative complication following pulmonary segmentectomy and should receive greater clinical attention. Tobacco exposure, tumor location, type of surgery, vagus nerve injury, and drainage duration were identified as independent risk factors for persistent cough after surgery. Visualizing these risk factors aids in assessing the likelihood of persistent cough after pulmonary segmentectomy and provides valuable support for clinical decision-making.
Keywords: Thoracoscopic surgery1, Segmentectomy2, Cough3, prediction model4, Nomogram5
Received: 02 May 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Guan, Han, Wan, Huang, Wei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiwei Li, Henan Provincial People's Hospital, Zheng zhou, China
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