CASE REPORT article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1624376
Meigs syndrome was misdiagnosed as a malignant ovarian tumor: A case report
Provisionally accepted
- Fuda Cancer Hospital, Guangzhou, China
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Abstract Background: Meigs syndrome is characterized by the association of a benign ovarian tumor, typically an ovarian fibroma, with pleural effusion and ascites. Case sumary: This report presents a case of a 54-year-old woman who was misdiagnosed with malignant ovarian neoplasm due to the presence of significant abdominal distension and elevated CA125 levels. Initial imaging at multiple external facilities suggested a left-sided malignant ovarian tumor, leading to unnecessary delays in treatment. Upon admission to our institution in April 2024, imaging confirmed a large pelvic mass, and subsequent diagnostic procedures indicated a likely fibroma. Surgical intervention revealed a left ovarian thecoma, and postoperative pathology confirmed the diagnosis. Notably, CA125 levels decreased from 335.1 U/ml to 164.6U/ml following surgery, and the patient showed significant clinical improvement. Conclusion: This case underscores the importance of considering Meigs syndrome in patients presenting with ovarian masses, pleural effusions, and elevated CA125, to prevent misdiagnosis and ensure timely management.
Keywords: Ovarian fibroma tumor, Pleural Effusion, Ascites, CA125, Meigs Syndrome
Received: 07 May 2025; Accepted: 25 Aug 2025.
Copyright: © 2025 Li, Xing, Hong, Ma and Niu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yangyang Ma, Fuda Cancer Hospital, Guangzhou, China
Lizhi Niu, Fuda Cancer Hospital, Guangzhou, China
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