SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Genitourinary Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1625901
Comparative Efficacy of Holmium Laser Versus Plasma Techniques in the Surgical Management of Non-Muscle Invasive Bladder Cancer: A Meta-Analysis
Provisionally accepted
- Jiashan First People's Hospital, Jiaxing, China
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Background: This systematic review and meta-analysis compared the efficacy of Holmium Laser and Plasma Techniques in treating non-muscle invasive bladder cancer (NMIBC), focusing on surgical duration, safety, and tumor recurrence.Methods: Adhering to PRISMA guidelines, we included randomized controlled trials that directly compared Holmium Laser and Plasma Techniques in NMIBC treatment. The Cochrane Collaboration's tool assessed study quality, and statistical analyses were conducted using fixed-effect or random-effects models based on heterogeneity. Sensitivity analyses and publication bias assessments were also performed.Our search yielded 1158 potentially relevant articles, with 8 studies meeting our inclusion criteria. The analysis showed no significant difference in surgical duration between the two techniques. However, the Holmium Laser was associated with a significantly lower incidence of intraoperative bladder perforation (RR=0.10, P<0.001) and a reduced short-term tumor recurrence rate (RR=0.65, P<0.01). Sensitivity analysis confirmed the robustness of these findings, and no significant publication bias was detected.Holmium Laser provides safer outcomes and better efficacy in reducing postoperative tumor recurrence compared to Plasma Techniques in NMIBC management.
Keywords: Non-muscle invasive bladder cancer, Holmium laser, Plasma techniques, metaanalysis, surgical outcomes
Received: 09 May 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Li, Xu, Chen, Ren and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yu-Min Li, Jiashan First People's Hospital, Jiaxing, China
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