SYSTEMATIC REVIEW article
Front. Oncol.
Sec. Gynecological Oncology
Artificial Intelligence Based on Ultrasound for Initial Diagnosis of Malignant Ovarian Cancer: A Systematic Review and Meta-Analysis
Provisionally accepted
- People's Hospital of Guangxi Zhuang Autonomous Region, Gaoxian,Yibin, China
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Purpose: This meta-analysis aimed to evaluate the diagnostic performance of artificial intelligence (AI) in ultrasound imaging for the initial diagnosis of malignant ovarian cancer, comparing its performance to that of sonographers. Methods: A systematic literature search was conducted in PubMed, Web of Science, Embase, and the Cochrane Library up to February 2025. Inclusion criteria targeted studies employing AI algorithms to analyze ultrasound images in patients with suspected ovarian cancer, using pathology as the reference standard. Bivariate random-effects models were utilized to aggregate sensitivity, specificity, and area under the curve (AUC). The methodological quality of the included studies was assessed using a modified version of the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. Results: Eighteen studies encompassing a total of 22,697 total patients/images/lesions were analyzed. AI demonstrated a sensitivity of 0.95 (95% CI: 0.88-0.98) and specificity of 0.95 (95% CI: 0.89-0.98) in internal validation sets, yielding an AUC of 0.98. In external validation, sensitivity was 0.78 (95% CI: 0.56-0.91) and specificity was 0.88 (95% CI: 0.76-0.95), with an AUC of 0.91. In comparison, sonographers exhibited a sensitivity of 0.83 (95% CI: 0.62-0.94), specificity of 0.84 (95% CI: 0.79-0.88), and an AUC of 0.87. These results indicate that ultrasound-based AI significantly outperforms sonographer diagnostics. Meta-regression analysis indicated that the heterogeneity was primarily attributed to the analysis method (image-based vs. patient-based, specificity P = 0.01). Conclusions: AI based on ultrasound diagnosis demonstrates excellent performance for malignant ovarian cancer detection, with potentially superior performance compared to sonographers. Despite high heterogeneity across studies and the observed publication bias, these results indicate the potential for AI integration into clinical practice. Further studies with external, multicenter prospective head-to-head design are still needed.
Keywords: artificial intelligence, Ovarian Neoplasms, Ultrasonography, diagnosis, Meta-analysis
Received: 10 May 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Li, Lei, Tang, Zheng, Qu, Xu and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Rong Li, 280259077@qq.com
Hongyu Zheng, zhenghongyu@hotmail.com
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