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CASE REPORT article

Front. Oncol.

Sec. Thoracic Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1626336

Case Report: Two Cases of Primary Pulmonary Endobronchial Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue Localized in the Trachea and Bronchus

Provisionally accepted
  • First Affiliated Hospital of Dalian Medical University, Dalian, China

The final, formatted version of the article will be published soon.

Background: Primary pulmonary extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) localized in the trachea and bronchus is rare and diagnostically challenging due to nonspecific clinical and radiological features. Case description: We present two cases of primary endobronchial MALT lymphoma incidentally diagnosed via bronchoscopy. We assessed the characteristic bronchoscopic finding of endobronchial MALT lymphoma, radiological examinations and overall treatment strategies. Conclusion: This study highlights the importance of considering endobronchial MALT lymphoma as a potential diagnosis. A thorough bronchoscopic evaluation of the central airways, along with appropriate biopsy of suspicious lesions, is crucial. Endobronchial MALT lymphoma should be suspected when targeting multiple widely stalked and smooth submucosal nodules or protrusions, mainly located in the central airways.

Keywords: Primary pulmonary lymphoma (PPL), MALT lymphoma, Wait and watch approach, PET-CT, transbronchial biopsy (TBB)

Received: 10 May 2025; Accepted: 29 Jul 2025.

Copyright: © 2025 Sha, Cai, Feng and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Chang Dong, First Affiliated Hospital of Dalian Medical University, Dalian, China

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