CASE REPORT article
Front. Oncol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Case Report: A New Noninvasive Device-Based Treatment of a Mesencephalic H3 K27M Glioma
Provisionally accepted
- 1Houston Methodist Research Institute, Houston, United States
- 2Weill Cornell Medical College, New York, United States
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ABSTRACT Brainstem gliomas have a poor prognosis and ineffective therapeutic options. We have developed a noninvasive device called an Oncomagnetic device that produces selective oncolysis of gliomas in vitro and marked reduction of contrast-enhanced tumor (CET) volume in end-stage recurrent glioblastoma (GBM) patients. Here we report Oncomagnetic treatment (OMT) of a 28-year-old woman who had undergone partial surgical excision and radiotherapy of a H3 K27M midline glioma in the mesencephalon and pons. OMT initiated after the first recurrence of the tumor was well tolerated for more than 694 days by the patient. There was near-complete regression of the CET at 145 days with symptomatic relief and a partial regression at 554 days after an apparent progression at 518 days. OMT was discontinued after 694 days because of hospital admission due to injuries from a fall and disease progression, which then led to her death. These findings demonstrate the potential of a new effective, nontoxic, and noninvasive wearable device-based treatment for the deadly diffuse midline glioma.
Keywords: Spinning oscillating magnetic fields, Magnetic Resonance Imaging, contrast enhanced tumor, compassionate use treatment, Magnetic Resonance Spectroscopy, wearable anti-cancer device
Received: 11 May 2025; Accepted: 24 Oct 2025.
Copyright: © 2025 Helekar, Ijare, Sharpe, Pichumani and Baskin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Santosh A Helekar, sahelekar@houstonmethodist.org
David Baskin, dbaskin@houstonmethodist.org
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