ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1627024
This article is part of the Research TopicCutting-Edge Strategies in Screening, Prevention, and Treatment in Gynaecologic OncologyView all 7 articles
Clinical and Prognostic Outcomes of Colposcopy-Guided LEEP Versus Cold Knife Conization in the Management of Cervical Intraepithelial Neoplasia
Provisionally accepted
- Guang'an People's Hospital, Guang'an, China
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Objective: To evaluate the clinical effectiveness and prognostic outcomes of colposcopy-guided LEEP compared with cold knife conization (CKC) in the treatment of cervical intraepithelial neoplasia (CIN). Methods: 124 patients with CIN in our hospital from January 2022 to December 2023 were chosen and classified into the control group (62 cases) and the observation group (62 cases) according to the therapeutic schedule. The observation group was treated with colposcopy combined with LEEP, while the control group underwent conventional cold knife conization (CKC). The clinical effect, surgical indicators, complicationswere compared. The control group underwent LEEP without colposcopic guidance, following standard clinical protocol. Results: The efficacy of the observation group was markedly better than that of the control group (95.16% vs. 75.81%, χ² = 9.358, P = 0.002). The operative time (35.35 ± 2.81 vs. 56.92 ± 2.17 minutes), intraoperative blood loss (8.08 ± 0.27 vs. 16.03 ± 2.27 mL), vaginal bleeding time (7.76 ± 1.85 vs. 11.37 ± 2.45 days), and hospital stays (2.74 ± 0.97 vs. 6.73 ± 1.33 days) were all significantly shorter in the observation group (P < 0.001). The complication rate was also lower (6.45% vs. 20.97%, P = 0.019). Conclusion: The findings suggest that this combined therapy is not only more effective but may also improve pregnancy outcomes for patients, making it a promising option for clinical application.
Keywords: Colposcopy, LEEP, CIN, clinical efficacy, Prognostic effect
Received: 12 May 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Jin, Wang and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhan Su, Guang'an People's Hospital, Guang'an, China
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