ORIGINAL RESEARCH article
Front. Oncol.
Sec. Gynecological Oncology
This article is part of the Research TopicEnhanced Recovery After Vascular Surgery: State of the Art and Future PerspectivesView all 4 articles
The effect of enhanced recovery after surgery on the risk factors of venous thromboembolism for patients with gynecologic malignancies
Provisionally accepted
- Yancheng Third People's Hospital, Yancheng, China
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Objective: This study aims to evaluate the efficacy of enhanced recovery after surgery (ERAS) in mitigating the risk of venous thrombosis in patients undergoing surgery for gynecological malignancies. Methods: This prospective randomized controlled trial enrolled patients from January 2019 to December 2022, who were randomly assigned to either the experimental group (ERAS management) or a control group (conventional treatment). The primary endpoints were perioperative venous thrombosis risk indicators, while secondary outcomes involved the incidence of venous thromboembolism (VTE) events and other clinically relevant adverse events. Results: A total of 177 patients were included, with 91 in the experimental group and 86 in the control group. Preoperative characteristics were comparable between the groups (P>0.05). At one-week post-surgery, the experimental group exhibited higher hemoglobin levels and lower white blood cell counts, D-dimer values, and proportions of patients classified as high risk for thrombosis compared to the control group (P<0.05). Additionally, the incidence of VTE events was significantly lower in the experimental group one month post-surgery (P<0.05). Conclusion: The implementation of ERAS significantly reduces perioperative venous thrombosis risk in patients with gynecological malignancies, demonstrating both safe and effective.
Keywords: Enhanced recovery surgery, gynecologic malignancies, Venous Thromboembolism, Risk factors, adverse events
Received: 13 May 2025; Accepted: 27 Oct 2025.
Copyright: © 2025 Xu, Liu, Liu, Wang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Meilan Tang, nqy484621sci@163.com
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