METHODS article
Front. Oncol.
Sec. Surgical Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1627742
This article is part of the Research TopicRecent Advancements and New Developments in Reconstructive SurgeryView all 3 articles
Clinical outcomes of xenogeneic acellular dermal matrix combined with full-thickness skin graft in the eyelid reconstruction following the excision of eyelid malignant tumors
Provisionally accepted
- 1First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- 2Gannan Medical University, Ganzhou，Jiang xi, China
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Objective: This study investigates the clinical efficacy of using the xenogeneic acellular dermal matrix (XADM) combined with full-thickness skin graft (FTSG) to reconstruct full-thickness eyelid defects following the excision of large malignant tumors.This single-center retrospective observational study analyzed 21 patients who received XADM combined with FTSG for full-thickness eyelid defects reconstruction following tumor resection at our hospital between January 2020 and September 2022. The study was reported according to the STROBE statement reporting guidelines. The cases included 13 basal cell carcinomas, one meibomian gland carcinoma, and seven squamous cell carcinomas. In the first-stage surgery, XADM combined with a FTSG was used to reconstruct the full-thickness eyelid defect. In the postoperative, a pressure dressing was applied for 5 days removing stitches at 2 weeks. Repair outcomes were assessed at 1, 3, and 6 months postoperatively. At the 6 months postoperative followup, second-stage surgery was performed to separate the upper and lower eyelids, restoring normal eyelid anatomy and function.Results: At 2 weeks postoperatively, all graft marginal sutures were well-aligned, and no graft necrosis was observed after sutures were removed. No complications were found during the followup at 1 and 3 months postoperatively. At 6 months postoperatively, separation of upper and lower eyelid adhesions was performed. Slit-lamp examination post eyelid separation surgery reveals the overall healing outcome was satisfactory, with no significant inflammatory response or rejection observed. The overall healing outcome was satisfactory, with no significant inflammatory response or rejection observed. All 21 patients recovered well postoperatively. No significant complications were observed in any patient, with only one patient exhibiting mild lagophthalmos.In full-thickness eyelid reconstruction following the excision of eyelid malignant tumors, using XADM for reconstructing the posterior lamella and conjunctiva, combined with FTSG for repairing the eyelid skin and soft tissue, is a recommended approach.
Keywords: xenogeneic acellular dermal matrix1, full-thickness skin graft2, eyelid reconstruction3, surgical approach4, eyelid malignant tumors5
Received: 13 May 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Xie, Xie and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jing Xie, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
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