MINI REVIEW article
Front. Oncol.
Sec. Hematologic Malignancies
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1628144
Immunoparesis in Multiple Myeloma: A Current Overview
Provisionally accepted
Hong Feng Wang
Jianbin Chen*- Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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Multiple myeloma (MM) is a common hematologic malignancy characterized by clonal plasma cell proliferation. Despite significant therapeutic advancements with proteasome inhibitors, immunomod-ulatory drugs, and anti-B-cell maturation antigen (BCMA) therapies, the disease remains largely incurable. Immunoparesis a severe state of immune dysfunction, exhibits high prevalence in MM patients and profoundly impacts prognosis. This review summarizes the pathogenic mechanisms and clinical characteristics of immunoparalysis, with a focus on its impact on prognosis and early-onset infections, the effects of contemporary drug therapies on immunoparalysis, and immune reconstitution.
Keywords: Multiple Myeloma, Immunoparesis, Bone marrow microenvironment, prognosis, Infections, Immune reconstitution
Received: 13 May 2025; Accepted: 08 Sep 2025.
Copyright: © 2025 Wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianbin Chen, Department of Hematology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
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