ORIGINAL RESEARCH article
Front. Oncol.
Sec. Cancer Epidemiology and Prevention
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1629679
This article is part of the Research TopicCancer Epidemiology: Patterns, Causes, and Therapeutic AdvancementsView all articles
Burden of Malignant neoplasm of bone and articular cartilage from 1990 to 2021 and its predictions to 2030 in China compared with World
Provisionally accepted
- 1Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
- 2Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- 3Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China
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Abstract Objective: To comprehensively examine the incidence and mortality of malignant neoplasms of bone and articular cartilage (MNBAC) in China compared with the world, as well as its age-specific patterns and sex disparities. Methods: The MNBAC burden in China and the world was systematically assessed from 1990 to 2021 based on the Global Burden of Disease 2021, including incidence and mortality data. The estimated annual percentage change was calculated. The pattern of age and gender distribution was carried out. The future trends of MNBAC incidence and mortality through 2030 were predicted using the Bayesian age-period-cohort model. Results: From 1990 to 2021, China experienced rising trends in both the incidence and mortality of MNBAC, increasing at a much faster pace than the world. Before 2005, crude incidence and mortality rates in China increased but plateaued thereafter. In contrast, age-standardized rates displayed a decreasing trend from 2005 onward. During this period, the world experienced relatively stable incidence and mortality rates. The incidence and mortality rates of MNBAC increase with age. The MNBAC burden is higher in males. The rise in incidence and mortality rate in China was predominantly in the elderly. The burden prediction for MNBAC to 2030 showed that China would experience a more significant drop in incidence and mortality rates for MNBAC, along with a decrease in the incidence and mortality cases. Conclusions: From 1990 to 2021, the MNBAC burden in China remains heavy, with incidence and mortality increasing much faster than in the world. The projection results indicate a promising outlook for the future, which is encouraging news. Men and the elderly should be the key target for the public health policies of MNBAC.
Keywords: malignant neoplasm of bone and articular cartilage, China, Epidemiology, Incidence, Mortality, GBD 2021
Received: 16 May 2025; Accepted: 06 Aug 2025.
Copyright: © 2025 Chen, Zheng, Zhang, Li, Li, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Cheng Chen, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
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