CASE REPORT article
Front. Oncol.
Sec. Breast Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1629690
Case Report: Personalized Treatment in Stage IV Breast Cancer Using the Patient-Derived Organoids
Provisionally accepted
- 1Department of Thyroid and Breast Surgery, Changhai Hospital, Naval Medical University, Shanghai, China
- 2Department of Breast and Thyroid Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
- 3The 906th Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army, Ningbo, China
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Breast cancer, especially stage IV breast cancer, is highly heterogeneous at morphological and molecular levels. Recently, the role of patient-derived organoids (PDOs) has become increasingly prominent in cancer research and personalized medicine. They are not only used to predict the clinical responses of patients with multiple cancer types, but also applied to drug development. In this study, we reported a case of stage IV breast cancer who responded well to sacituzumab govitecan that was highly sensitive by the PDO-based drug sensitivity testing, good pathological response was obtained postoperatively. This typical case suggests that PDO-based drug sensitivity testing is conductive to tailoring neoadjuvant chemotherapy options to enhance the feasibility of surgical resection in patients with stage IV breast cancer, thus improving the prognosis.
Keywords: Stage IV breast cancer, patient-derived organoids, Sacituzumab govitecan, Neoadjuvant Therapy, Pathological response
Received: 16 May 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 Ying, Pi, He and Sheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuan Sheng, Department of Breast and Thyroid Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China
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