CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1630104
An Innovative Treatment Approach Using Iliac Artery Embolization and Implanted Port for Chemotherapy in a Patient with Gluteal Muscle Metastasis of Advanced Colon Cancer: A Case Report and Literature Review
Provisionally accepted
- Anhui No 2 Provincial People's Hospital, Hefei, China
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Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, with metastasis often resulting in significant treatment challenges. This case report describes a 54year-old male patient who presented with a rectal cancer metastatic mass accompanied by erosion in the left gluteal area, diagnosed as poorly differentiated adenocarcinoma, along with significant cachexia and pelvic and lymph node metastases. Despite undergoing CAPEOX chemotherapy, no notable tumor shrinkage was observed. In light of this, a multidisciplinary consultation led to the adoption of an innovative approach that included transiliac artery chemotherapy embolization and the implantation of an arterial chemotherapy pump for mFOLFOX6 combined with bevacizumab.Following four cycles of reduced-dose arterial infusion chemotherapy, the tumor in the gluteal region demonstrated a remarkable reduction of approximately 90%. This case showcases a promising treatment modality that integrates localized arterial embolization and chemotherapy, along with supportive care. The approach significantly improved the patient's quality of life and extended survival in individuals facing advanced colorectal cancer with gluteal muscle metastasis, suggesting that this therapy merits further investigation and potential implementation in clinical practice.
Keywords: case report, colorectal cancer, Iliac Artery Embolization, Intra-arterial chemotherapy, Gluteal Muscle Metastasis
Received: 16 May 2025; Accepted: 20 Aug 2025.
Copyright: © 2025 Wang, Zong, Tang and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sen Wang, Anhui No 2 Provincial People's Hospital, Hefei, China
Yuan-Dong Wei, Anhui No 2 Provincial People's Hospital, Hefei, China
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