Association between ESRα and ESRβ polymorphisms and prostate cancer risk: Meta-Analysis

Bai Xiaohui^1*Gao Li¹Zhao Jiawei²Liao Wentao¹Chen Yujing²Guo Xiaotong²Jin Jiamin^2*Bo Ge^1*

• ¹Department of Urology, The Second Affiliated Hospital of Guilin Medical University, Guilin, China
• ²Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin, China

Background: Gene polymorphisms of ESRα Pvull(rs2234693), Xbal(rs9340799), and ESRβ Alul(rs4986938), Rsal(rs1256049) and the risk of prostate cancer had been investigated . Unfortunately, the nature of the relationship remains ambiguous. Therefore, present study will further corroborate the relationship between the risk of ESR and prostate cancer. Objective: To investigate the risk of ESRα Pvull(rs2234693), Xbal(rs9340799), and ESRβ Alul(rs4986938), Rsal(rs1256049) and prostate cancer risk. Materials and Methods: PubMed, Medline, and CNKI, were searched. Association was assessed using odds ratio (OR) with 95% confidence interval (CI). Moreover, the false-positive reporting probability (FPRP), Bayesian false-finding probability (BFDP), and Venetian criteria were used to assess the credibility of statistically significant associations. Results: We found for the first time that in overall, ESRα Pvull were significantly reduced associated with the risk of prostate cancer (pp vs. Pp + PP: OR = 0.83, 95% CI = 0.71-0.97; pp vs. PP: OR = 0.75, 95% CI = 0.57-0.99; p vs. P: OR = 0.88, 95% CI = 0.78-0.99). Similarly, a depressed risk of prostate cancer was also ascertained‌ in Caucasians (pp + Pp vs. PP OR = 0.01, 95% CI = 0.01-0.04). However, we found ESRα Pvull polymorphisms increases the risk of prostate cancer of Africans (pp + Pp vs. PP: OR = 2.38, 95% CI = 1.61-3.51). Moreover, ESRβ Rsal and the risk of prostate cancer in the Caucasians. However, we found ESRβ Rsal polymorphisms were reduced associated with the risk of prostate cancer in Asians (r vs. R: OR = 0.87, 95% CI = 0.77-0.98). Unfortunately, we have not found the association between ESRα Xbal and ESRβ Alul and the risk of prostate cancer. When the credibility was evaluated applying FPRP, BFDP, and Venetian criteria, did not found positive results. Conclusions: In conclusion, results showed a robust association between the ESRα Pvull and ESRβ Rsal polymorphism and the risk of prostate cancer.