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CASE REPORT article

Front. Oncol.

Sec. Gynecological Oncology

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1631424

A Rare Case of Hepatoid Carcinoma of the Ovary with Genomic Profiling and Long-term Follow-up: Diagnostic and Therapeutic Perspectives

Provisionally accepted
Yufang  ZuoYufang Zuo1Xuan  LiuXuan Liu1,2Yajun  PangYajun Pang1Xiaowen  ChenXiaowen Chen1Xiaofang  LiXiaofang Li1Jiangsheng  GaoJiangsheng Gao2Bingjie  LiuBingjie Liu2Sihai  LiaoSihai Liao1*Ying  ZhangYing Zhang1*Chengnong  GuanChengnong Guan3*
  • 1Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
  • 2Guangdong Medical University, Zhanjiang, China
  • 3Dongguan First Hospital affiliated to Guangdong Medical University, Dongguan, China

The final, formatted version of the article will be published soon.

Hepatoid carcinoma of the ovary (HCO) is a highly uncommon and aggressive neoplasm originating from the surface epithelial cells of the ovary, characterized by hepatocyte-like differentiation. To date, most information on HCO is derived from case reports, with fewer than 50 documented cases globally. In this case report, we present a detailed account of the diagnosis, treatment, and prognosis of a patient diagnosed as having bilateral HCO, which is even rarer. Targeted next-generation sequencing revealed somatic mutations in PIK3C3 and TP53, with no BRCA1/2 alterations, and a molecular profile consistent with microsatellite stability and low tumor mutational burden. We also review the current literature to situate our findings within the broader context of existing knowledge. Given the rarity of bilateral HCO, our objective is to contribute to the existing body of knowledge by providing a comprehensive description of its clinical features, molecular characteristics, and treatment strategies. This effort may enhance understanding of this rare malignancy and offer insights to improve patient outcomes in clinical practice.

Keywords: Hepatoid carcinoma of the ovary, diagnosis, multidisciplinary, case report, Alpha-Fetoprotein

Received: 19 May 2025; Accepted: 04 Aug 2025.

Copyright: © 2025 Zuo, Liu, Pang, Chen, Li, Gao, Liu, Liao, Zhang and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Sihai Liao, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
Ying Zhang, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China
Chengnong Guan, Dongguan First Hospital affiliated to Guangdong Medical University, Dongguan, China

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