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REVIEW article

Front. Oncol.

Sec. Cancer Imaging and Image-directed Interventions

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1631951

This article is part of the Research TopicThe Contrast Enhanced Ultrasound and Ultrasound Cavitation in the Diagnostic and Therapeutic Application of Solid TumorView all articles

Ultrasound Technology in Dermatological Oncology: Integrated Review of Current Applications and Future Directions

Provisionally accepted
Jiaqi  LouJiaqi Lou1Ziyi  XiangZiyi Xiang2Xiaoyu  ZhuXiaoyu Zhu3Jiliang  LiJiliang Li1Qionghui  SunQionghui Sun1,4*Guoying  JinGuoying Jin1*Shengyong  CuiShengyong Cui1Neng  HuangNeng Huang1Xin  LeXin Le1Youfen  FanYoufen Fan1*
  • 1Burn Department, Ningbo No.2 Hospital, Ningbo, Zhejiang Province, China
  • 2Institute of Physiology I, Faculty of Medicine, University of Bonn, Bonn, Nordrhein-Westfalen, Germany
  • 3Department of Health Science Center, Ningbo University, Ningbo, Zhejiang, China
  • 4Department of Nursing, Ningbo No.2 Hospital, Ningbo, China

The final, formatted version of the article will be published soon.

This paper explores the critical role of ultrasound technology in enhancing the diagnosis and treatment methodologies for skin cancer. It delves into the applications of various ultrasound techniques, such as High-Frequency Ultrasound (HFUS), Contrast-Enhanced Ultrasound (CEUS), ultrasound elastography, and Artificial Intelligence (AI)-assisted diagnosis. The paper highlights the merits and constraints of each modality within clinical settings, alongside potential avenues for future research. Advances in technology, such as the development of ultra-high-frequency probes and adaptive focusing algorithms, are poised to significantly improve the imaging quality, especially for deep-seated tumors. The integration of AI, through the establishment of multicenter databases and sophisticated AI models, can potentially elevate the accuracy and consistency of diagnostics. Therapeutic innovations involving ultrasound-activated immunotherapies and targeted drug delivery systems offer promising perspectives for more effective and less invasive treatment methodologies. The paper concludes by emphasizing that sustained progress and collaboration in the field may establish ultrasound technology as a cornerstone in precision medicine for skin cancer, ultimately improving diagnostic and therapeutic outcomes for patients.

Keywords: ultrasound, diagnosis, Skin Cancer, contrast-enhanced ultrasound, High-frequency ultrasound

Received: 20 May 2025; Accepted: 08 Oct 2025.

Copyright: © 2025 Lou, Xiang, Zhu, Li, Sun, Jin, Cui, Huang, Le and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Qionghui Sun, tps20188@126.com
Guoying Jin, guoyingking@163.com
Youfen Fan, 13906683613@163.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.